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Selected Publications

McCaig CM, Lin X, Farrell M, Rehain-Bell K, and Shakes DC (2017). Germ cell cysts and stimultaneous sperm and oocyte production in a hermaphroditic nematode, Developmental Biology 430:362-373. doi: 10.1016/j.ydbio.2017.08.010. F1000 recommended.

Winter ES, Schwarz A, Fabig G, Feldman JL, Pires-daSilva A, Müller-Reichert T, Sadler PL, Shakes DC. (2017). Cytoskeletal variations in an asymmetric cell division support diversity in nematode sperm size and sex ratios. Development. 144(18): 3253-3263. doi: 10.1242/dev.153841.

Singaravelu G, Rahimi S, Krauchunas A, Rizvi A, Dharia D, Shakes D, Smith H, Golden A, and Singson A (2015) Forward genetics identifies a requirement for the Izumo-like immunoglobulin superfamily spe-45 gene in Caenorhabditis elegans fertilization. Current Biology 25(24) 3220-4. F1000 recommended

Chu DS and Shakes DC (2013) Spermatogenesis. In Germ Cell Development in C. elegans. Editor Tim Schedl. Advances in Experimental Medicine and Biology. Vol. 757: 171-203.

Kulkarni M, Shakes DC, Guevel K, and Smith HE (2012) SPE-44 implements sperm cell fate. PLoS Genetics 8(4): e1002678

Shakes DC, Miller DM, and Nonet ML (2012) Immunofluorescence microscopy. Methods in Cell Biology 107: 35-66 (Methods).

Geldziler BD, Marcello MR, Shakes DC, and Singson A. (2011) The Genetics and Cell Biology of Fertilization. Methods in Cell Biology 106: 343-75 (Methods).

Shakes DC (2011) For male Caenorhabditis elegans, sperm activation is a "just-in time" event. PLoS Genetics 7(11): e1002392. (invited perspectives article)

Shakes DC, Allen AK, Albert KM, and Golden A (2011) emb-1 encodes the APC16 subunit of the C. elegans anaphase-promoting complex.Genetics 189(2): 549-60.

Shakes DC, Neva BJ, Huynh H, Chaudhuri J, and Pires-daSilva A. (2011) Asymmetric spermatocyte division as a mechanism for controlling sex ratios. Nature Communications 2 : 157  doi: 10.1038/ncomms1160

Featured in the news: W&M article, BBC Earth

Wu TF, Nera B, Chu DS, and Shakes DC (2010) Elucidating gene regulatory mechanisms for sperm function through the integration of classical and systems approaches in C. elegans. Systems Biology in Reproductive Medicine 56(3): 222-35.

Shakes DC, Wu J, Sadler PL, LaPrade K, Moore LL, Noritake A, and Chu DS (2009) Spermatogenesis-specific features of the C. elegans meiotic program. PLoS Genetics 5(8) e1000611.

Chatterjee I, Richmond A, Putiri E, Shakes DC, and Singson A. (2005)  The Caenorhabditis elegans spe-38 gene encodes a novel tetraspan integral membrane protein required for sperm function and fertilization. Development 132: 2795-2808.

Frazier T, Shakes D, Hota U, and Boyd L (2004) Caenorhabditis elegans UBC-2 functions with the anaphase promoting complex but also has other activities. J. Cell Science 117: 5427-35

Shakes DC, Sadler PL, Schumacher JM, Abdolrasulnia M, and Golden A. (2003) Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities. Development 130: 1605-1620.

Davis ES, Wille L, Chestnut B, Sadler P, Shakes D, and Golden A. (2002) Multiple subunits of the C. elegans Anaphase Promoting Complex are required for chromosome segregation during meiosis I. Genetics 160: 805-813.

Morton DG, Shakes DC, Nugent S, Dichoso D, Wang W, Golden A, and Kemphues KJ. (2002) The C. elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo. Developmental Biology 241: 47-58. F1000 recommended.

Golden, A., Sadler PL, Wallenfang MR, Schumacher JM, Hamill DR, Bates G, Bowerman B, Seydoux G, and Shakes DC (2000). Metaphase to anaphase transition defective (mat) mutants in Caenorhabditis elegans.  J. Cell Biol. 151: 1469-1482.

Sadler, P.L. and D.C. Shakes. (2000) Anucleate C. elegans sperm can crawl, fertilize oocytes, and direct anterior-posterior polarization of the 1-cell embryo. Development 127(2): 355-366.

Wang, W. and Shakes, D.C.(1996) Molecular evolution of the 14-3-3 gene family. J. Mol Evol. 43: 384-398.

Epstein, H.F.  and D.C. Shakes (editors) (1995) C. elegans: Modern Biological Analysis of an Organism. Methods in Biology Series. Volume 48. Academic Press, San Diego.

Shakes, DC (1995) Fostering creativity in the science classroom: A science and arts projects. J. Coll. Sci. Teaching 24: 333-335. 

Shakes, DC and S Ward. (1989). Initiation of spermiogenesis in C. elegans: A pharmacological and genetic analysis. Dev. Biol. 134: 189-200.

Hill, DP, DC Shakes, S. Ward, and S. Strome. (1989). A sperm-supplied product essential for initiation of normal embryogenesis in Caenorhabditis elegans is encoded by the paternal-effect embryonic-lethal gene, spe-11. Dev. Biol. 136(1): 154-166.

L’Hernault, SW, DC Shakes, and S. Ward. (1988). Developmental genetics of chromosome I spermatogenesis-defective mutants in the nematode, C. elegans. Genetics 120(2): 435-452.