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[34] Young, D.D.; Deiters, A. "Chemo- and Regioselectivity Enhancements in Solid-Supported Reactions" 2011, Jon Wiley & Sons Inc. in press (Invited book chapter)

solid phase book chapter 2011


[33]  Dush, M.; McIver, A. L.; Parr, M.; Young, D. D.; Fisher, J.; Hauck, M. L.; Deiters, A.; Nascone-Yoder, N. M. “Heterotaxin: a TGF-b Signaling Inhibitor Identified in a Screen for Left-Right Asymmetric Organ Defects in Xenopus Embryos” Chem. Biol. 201118, 252-253.



chemistry and biology cover





[32] Karginov, A. V.; Zou, Y.; Shirvanyants, D.; Kota, P.; Dokholyan, N. V.; Young, D. D.; Hahn, K. M.; Deiters A. “Light-Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP” J. Am. Chem. Soc. 2011133, 420-423.








[31] Young, D. D.; Connelly, C. M.; Grohmann, C.; Deiters, A. “Small Molecule Modifiers of MicroRNA miRNA-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma” J. Am. Chem. Soc. 20101327976–7981.






[30] Young, D. D.; Lively, M. O.; Deiters, A. “Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells” J. Am. Chem. Soc. 2010132, 6183-6193.






[29] Chou, C.; Young, D. D.; Deiters, A. “Photocaged T7 RNA Polymerase for the Light-Activation of Transcription and Gene Function in Pro- and Eukaryotic Cells” ChemBioChem 201011, 972-977.

T7 RNA polymerase



[28] Wilkins, B. J.; Marionni, S.; Young, D. D.; Liu, J.; Wang, Y.; Di Salvo, M. L.; Deiters, A.; Cropp, T. A. “Site-specific Incorporation of Fluorotyrosines into Proteins in E. coli by Photochemical Disguise” Biochemistry 201049, 1557-1559.

Caged FY





[27] Young, D. D.; Teske, J. A.; Deiters, A. " Open-Vessel Microwave-Mediated [2+2+2] Cyclotrimerization Reactions” Synthesis< // --> /span> 200922, 3785-3790.

Open Vessel





[26] Chou, C.; Young, D. D.; Deiters, A. “A Light-Activated DNA Polymerase” Angew. Chem. Int. Ed. 2009121, 6064-6067.

caged taq


[25] Bereman, M. S.; Young, D. D.; Deiters, A.; Muddiman, D. C. “Development of a Robust and High Throughput Method for Profiling N-linked Glycans Derived from Plasma Glycoproteins by Nano LC FT-ICR Mass Spectrometry” J. Proteome Res. 20098, 3764-3770.

MW Mass Spec



[24] Edwards, W.E.; Young, D.D.; Deiters, A. “The Effect of Microwave Irradiation on DNA Hybridization” Org. Biomol. Chem. 20097, 2506-2508

mw DNA





[23] Edwards, W.E.; Young, D.D.; Deiters, A. “Light-Activated Cre Recombinase as a Tool for the Spatial and Temporal Control of Gene Function in Mammalian Cells” ACS Chem. Biol. 20094, 441-445.





[22] Young, D.D.; Govan, J.M.; Lively, M.O.; Deiters, A. “Photochemical Regulation of Restriction Endonuclease Activity” ChemBioChem200910, 1612-1616.

Restriction Enzyme





[21] Young, D. D; Lusic, H.; Lively, M.O.; Deiters, A. “Restriction Enzyme-Free Mutagenesis via the Light Regulation of DNA Polymerization” Nuc. Acids Res. 2009. e58.

Polymerase Stop



[20] Young, D. D.; Garner, R. A.; Yoder, J. A.; Deiters, A. "Light Activation of Gene Function in Mammalian Cells via Ribozymes", Chem. Commun. 2009568-570.




[19] Young, D.D.; Torres-Koblus, J.; Deiters, A. “Microwave-Assisted Synthesis of Unnatural Amino Acids”, Bioorg. Med. Chem. Lett.2008, 5478-5480.

mw amino acid






[18] Young, D.D.; Lusic, H.; Lively, M.O.; Yoder, J.A.; Deiters, A. “Gene Silencing with Light-Activated Antisense Agents”, ChemBioChem 20089, 2937-2940.




[17] Zou, Y.; Young, D.D.; Cruz, A.; Deiters, A. “Synthesis of Anthracene and Azaanthracene Fluorophores via [2+2+2] Cyclotrimerization Reactions”, Org. Lett.. 200810, 4661-4664.







[16] McIver, A.; Young, D. D.; Deiters, A. "A General Approach to Triphenylenes and Azatriphenylenes: Total Synthesis of Dehydrotylophorine and Tylophorine", Chem. Commun. 2008, 4750-4752.








[15] Young, D.D.; Nichols, J. Kelly; R.M.; Deiters, A. “Microwave Activation of Enzymatic Catalysis” J. Am. Chem. Soc. 2008130, 10048-10049.

microwave protein






[14] Gumireddy, K.; Young, D.D.; Xiong, X.; Hogenesch, J.B.; Huang, Q.; Deiters, A. “Small Molecule Inhibitors of MicroRNA miRNA-21” Angew. Chem. Int. Ed. 200847, 7482-7484.




[13] Young, D.D.; Deiters, A. “Light-Regulated RNA-Small Molecule Interactions” ChemBioChem 20089, 1225-1228.






[12] Young, D.D.; Edwards, W.F.; Lusic, H. Lively, M.O.; Deiters, A. “Light-Triggered Polymerase Chain Reaction” Chem. Commun. 2008, 462-464.





[11] Young, D.D.; Sripada, L.; Deiters, A. “Microwave-Assisted Solid-Supported Alkyne Cyclotrimerization Reactions for Combinatorial Chemistry” J. Comb. Chem. 2007, 9, 735-738.

combichem MW





[10] Senaiar, R.S.; Teske, J.A.; Young, D.D.; Deiters, A. “Total Synthesis of Indanones via [2+2+2] Cyclotrimerization” J. Org. Chem. 2007, 72, 7801-7804.  






[9] Young, D.D.; Deiters, A. “A General Approach to Chemo- and Regioselective Cyclotrimerization Reactions” Angew. Chem. Int. Ed. 2007 46, 5187-5190.

mw pyridine





[8] Lusic, H.; Young, D.D.; Deiters, A. “Photochemical DNA Activation” Org. Lett. 2007, 9, 1903-1906.






[7] Young, D.D.; Deiters, A. “Photochemical Activation of Protein Expression in Bacterial Cells” Angew. Chem. Int. Ed. 2007, 46, 4290-4292.






[6] Young, D.D.; Deiters, A. “Photoregulation of Gene Expression” Org. Biomol. Chem. 2007, 5, 999-1005. (invited review)





[5] Senaiar, R. S.; Young, D.D.; Deiters, A. "Pyridines via Solid-Supported [2+2+2] Cycloadditions" Chem. Commun. 2006, 1313-1315.





[4] Young, D.D.; Deiters, A. "Photochemical Activation of a Hammerhead Ribozyme" Bioorg. Med. Chem. Lett. 2006, 16,2658-2661.






[3] Young, D.D.; Senaiar, R. S.; Deiters, A. "Solid-Supported [2+2+2] Cycloadditions" Chem. Eur. J. 2006, 12, 5563-5568.