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Publications

Independent Research

[66] Travis, C.R.; Gaunt, G.H.; King, E.A.; Young, D.D. "Genetic Encoding of a Bioconjugation Handle for [2+2+2] Cycloaddition Reactions" ChemBioChem 2019. accepted (VIP Paper)

cyclotrimUAA

 

 

 

 

 

 

 

 

[65] Travis, C.R.; Mazur, L.E.; Peairs, E.M.; Gaunt, G.H.; Young, D.D. "Mechanistic Investigation and Further Optimization of the Aqueous Glaser-Hay Bioconjugation" Org. Biomol. Chem 2019 17, 3396-3402.

AqGHMech

 

 

 

 

 

 

 

[64] Young, D.D.; Schultz, P.G. "Playing with the Molecules of Life" ACS Chem. Biol. 2018 13, 854-870.

schultzrev

 

 

 

 

 

 

 

 

 

 

 

[63] Chatkewitz, L.E.; Halonski, J.F.; Padilla, M.S.; Young, D.D. "Investigation of Copper-Free Alkyne/Azide 1,3-Dipolar Cycloadditions Using Microwave Irradiation" Bioorg. Med. Chem Lett. 2018, 28, 81-84.

mwclick

 

 

 

 

 

 

 

 

 

 

[62] Nimmo, Z.M.; Halonski, J.F.; Chatkewitz, L.E.; Young, D.D. "Development of Optimized Conditions for Glaser-Hay Bioconjugations" Bioorg. Chem. 2018, 76, 326-331.

GHOPT

 

 

 

 

 

 

 

 

 

 

[61] Villa, J.K.; Tran, H.A.; Vipani, M.; Gianturco S.; Bhasin, K.; Russell B.L.; Harbron, E.J.; Young, D.D. "Fluorescence Modulation of Green Fluorescent Protein Using Fluorinated Unnatural Amino Acids" Molecules 2017, 22, 1194-1200.

FluoroGFP

 

 

 

 

 

 

 

 

 

[60] Maza, J.C.; Howard, C.A.; Vipani, M.A.; Travis C.R.; Young, D.D. "Utilization of Alkyne Bioconjugations to Modulate Protein Function" Bioorg. Med. Chem. Lett. 2017, 27, 30-33.

 

GFPGH

 

 

 

 

 

[59] Lampkowski, J.S.; Uthappa, D.M.; Maza, J.C.; Young, D.D. "Application of the Solid-Supported Glaser-Hay Reaction to Natural Product Synthesis" J. Org. Chem. 2016, 81, 12520-12524.

GHNatProd

 

 

 

 

 

 

 

[58] Padilla, M.S.; Farley, C.A.; Chatkewitz, L.E.; Young, D.D. "Synthesis and Incorporation of a Caged Tyrosine Amino Acid Posessing a Bioorthogonal Handle" Tet. Lett. 2016, 57, 4709-4712.

cagedtyrosine

 

 

 

 

 

[57] Maza, J.C.; Villa, J.K.; Landino, L.M.; Young, D.D. "Utilizing Unnatural Amino Acids to Illustrate Protein Structure-Function Relationships: An Experiment Designed for an Undergraduate Biochemistry Laboratory" J. Chem. Ed. 2016, 93,767-771.

UAAlab

 

 

 

 

 

 

 

 

 

 

[56] Maza, J.C.; Nimmo, Z.M.; Young, D.D.; "Expanding the Scope of Alkyne-Mediated Bioconjugations Utilizing Unnatural Amino Acids" Chem. Commun. 2016, 52, 88-91.

cccoup

 

 

 

 

 

[55] Maza, J.C.; Jacobs, T.H.; Uthappa, D.M.; Young, D.D.; "Employing Unnatural Amino Acids in the Preparation of Bioconjugates" Synlett 2016, 27, 805-813. (invited manuscript)

UAArev

 

 

 

 

 

 

 

 

 

[54] Lampkowski, J.S.; Uthappa, D.M.; Young, D.D.; "Site-Specific Incorporation of a Fluorescent Terphenyl Unnatural Amino Acid" Bioorg. Med. Chem. Lett. 2015, 25, 5277-5280.

 terphenyl.jpg

 

 

 

 

 

 

 

 

[53] Maza, J.C.; McKenna, J.R.; Raliski, B.K.; Freedman, M.T.; Young, D.D.; "Synthesis and Incorporation of Unnatural Amino Acids to Probe and Optimize Protein Bioconjugates" Bioconjug. Chem. 2015, 26,1884-1889.

 tethered

 

 

 

[52] Lampkowski; J.S.; Bass, W.; Nimmo, Z.M.; Young, D.D.; "Microwave-Assisted Esterifications: An Unknowns Experiment Designed for an Undergraduate Organic Chemistry Laboratory" W. J. Chem Ed. 2015, 3, 111-114.

mwlab

 

 

 

 

 

[51] Lampkowski, J.S.; Villa, J.K.; Young, T.S.; Young, D.D.; "Development and Optimization of Glaser-Hay Bioconjugations" Angew. Chem. Int. Ed. 2015 54, 9343-9346.

Bioconj GH

 

 

 

 

 

[50] Lampkowski, J.S.; Maza, J.C.; Verma, S.; Young, D.D.; "Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave" Molecules 2015, 20, 5276-5285. (invited paper)

Microwave GH

 

 

 

 

 

 

 

 [49] Padilla, M.S.; Young, D.D.; "Photosensitive GFP Mutants Containing an Azobenzene Unnatural Amino Acid." Biol. Med. Chem. Lett. 2015, 25, 470-473.

AzoGFP.jpg

 

 

 

 

 

 

 

[48] Lampkowski, J.S.; Durham, C.E.; Padilla, M.S.; Young, D.D.; "Preparation of Asymmetrical Polyynes by a Solid-Supported Glaser-Hay Reaction." Org. Biomol. Chem. 2015, 13, 424-427.

asymmetric polyyne

 

 

 

 

 

[47] Raliski, B.K.; Howard, C.A.; Young, D.D.; "Site-Specific Protein  Immobilization Using Unnatural Amino Acids." ACS Bioconj. Chem. 2014.  25, 1916-1920.

uaa immobilization

 

 

 

 

 

 

 

 

 

 

[46] Muetteries, C.; Janiga, A.; Huynh, K.; Pisano, M.G.; Tripp, V.T.; Young, D.D.; Poutsma, J.C.; "Gas-Phase Acid-Base Properties of Homocysteine, Homoserine, and 5-Hydroxynorvaline from the Extended Kinetic Method." J. Mass. Spectrom. in press.

homocys ms

 

 

 

 

 

[45] Tripp, V.T.; Lampkowski, J.S.; Tyler, R.; Young, D.D.; "Development of Solid-Supported Glaser-Hay Couplings." ACS Combi. Sci. 2014. 16, 164-167.

 glaserhay

 

 

 

 

 

[44] Rust, H.; Subramanian, V.; West, G.; Young, D.D.; Schultz. P.G.; Thompson, P.; "Using Unnatural Amino Acid Mutagenesis to Probe the Regulation of PRMT1." ACS Chem. Biol. 2014. 9, 649-655.

 

prmt1

 

 

 

 

 

 

 

 

[43] Govan, J.M.; Young, D.D.; Lusic, H.; Liu, Q.; Lively, M.O.; Deiters, A.; "Optichemical Control of RNA Interference in Mammalian Cells." Nuc. Acids Res. 2013. 41, 10518-10528.

RNAi

 

 

 

 

[42] Tripp, V.T.; Maza, J.C.; Young, D.D.; "Development of Rapid Microwave Mediated and Low Temperature Bacterial Transformations." J. Chem. Biol. 2013. 6, 135-140.

mwtransformation 

 

 

 

 

 

[41] Tripp, V.T.; McKenna, J.R.; Young, D.D.; "Approaches to the Modulation of miRNA Maturation." Christoph Arenz (ed.) miRNA Matuation. Methods in Molecular Biology. 2013. Springer Science Press. 27-58 (Invited Book Chapter)

 [40] Tripp, V.T.; Young, D.D.; "Discovery of Small Molecule Modifiers of microRNAs for the Treatment of HCV Infection." Daniel Lafontaine and Audre Dube (ed.) Therapeutic Applications of Ribozymes and Riboswitches. Methods in Molecular Biology, 2013, Humana Press 153-166. (Invited Book Chapter)

[39] Georgianna, W.E.; Young, D.D. “Development and Utilization of Non-Coding RNA-Small Molecule Interactions.” Org. Biomol. Chem. 2011, 9, 7969-7978. (Invited Review) 

 OBC miRNA

 

 

 

 

 

 

Postdoctoral Research

[38] Minnihan, E.C.; Young, D.D.; Schultz, P.G.; Stubbe, J. "Incorporation of Fluorotyrosines into Ribonucleotide Reductase Using Evolved, Polyspecific Aminoacyl-tRNA Synthetase" J. Am. Chem. Soc. 2011, 133, 15942-15945.

 fluorotyrosine JACS 2011

 

 

[37] Young, D.D.; Jockush, S.; Turro, N.J.; Schultz, P.G. "Synthetase Polyspecificity as a Tool to Modulate Protein Function" Bioorg. Med. Chem. Lett. 2011, 21, 7502-7504.

                                            coumarin_polyspecificity 

 

 

[36] Young, T.S.; Young, D.D.; Ahmad, I.; Louis, J.M.; Benkovic, S.J.; Schultz, P.G. “Evolution of Cyclic Peptide Protease Inhibitors with Synthetic Building Blocks” Proc. Nat. Acad. Sci. 2011, 108, 11025-11056.

cyclic peptide

 

 

 

 

 

[35] Young, D.D.; Young, T.S.; Jahnz, M.; Ahmad, I.; Spraggon, G.; Schultz. P.G. “Evolved Aminoacyl-tRNA Synthetases with Atypical Polysubstrate Specificity” Biochemistry. 2011, 50, 1894-1900.

 polyspecificity

 

 

 

 

 

Graduate Research

Undergraduate Research