Masthead image

Publications (undergraduate names in bold font):


  1. Robert J. Hinkle, Daniel J. Speer, Brendon B. Carnell, Bethany L. Kanter, Robert D. Pike, "Mild, Modular and Convergent Synthesis of Helical Naphtho[2.1-c]chromenes via a Multistep Cyclization/Aromatization Cascade Sequence," J. Org. Chem. 2019, 84, 15633-15640:
  2. Robert J. Hinkle, Sarah E. Bredenkamp, Robert D. Pike, Seong Ik Cheon, “Electrophilic Cyclization of Phenylalkynediols to Naphthyl(aryl)iodonium Triflates with Chelating Hydroxyls: Preparation and X-ray Analyses ,” J. Org. Chem. 2017, ASAP  article published online 17 August 2017. DOI: 10.1021/acs.joc.7b01619 (
  3. Robert J. Hinkle, Yuzhou Chen, Colleen Nofi, and Shane E. Lewis, “Electronic effects on a one-pot aromatization cascade involving alkynyl-Prins cyclization,Friedel–Crafts alkylation and dehydration totricyclic benzo[f]isochromenes,” Org. Biomol. Chem. 2017. Published online 11 August 2017; DOI:
  4. Robert J. Hinkle, Shane E. Lewis, "“Atom Economical, One-Pot, Three-Reaction Cascade to Novel Tricyclic 2,4-Dihydro-1H-benzo[f]isochromene Derivatives,” Org. Lett. 2013, 15, 4070-4073. ASAP published online 01 August 2013; DOI
  5. Frederick Lambert, Robert J. Hinkle,* Stephen E. Ammann, Yajing Lian, Jia Liu, Shane E. Lewis, and Robert D. Pike, “Bi(OTf)3-, TfOH-, and TMSOTf-Mediated, One-Pot Epoxide Rearrangement, Addition, and Intramolecular Silyl-Modified Sakurai (ISMS) Cascade toward Dihydropyrans: Comparison of Catalysts and Role of Bi(OTf)3 J. Org. Chem. 2011, 76, 9269-9277.
  6. Hinkle, R. J.; Lian, Y.; Speight, L. C.; Stevenson, H. E.; Sprachman, M. M.; Katkish, L. A.; Mattern, M. C. ” Synthesis of 2,6-Disubstituted Dihydropyrans via an Efficient BiBr3-initiated Three Component, One-pot Cascade,” Tetrahedron. 2009, 65, 6834–6839.
  7. Lian, Y.; Hinkle, R. J. ”BiBr3-Initiated Tandem Addition/Silyl-Prins Reactions to 2,6-Disubstituted Dihydropyrans,” J. Org. Chem. 2006, 71, 7071-7074.
  8. Robert J. Hinkle, Lian, Y.; Litvinas, N. D.; Jenkins, A. T.; Burnette, D. C. "Bismuth(III) Bromide Initiated Cyclization-Addition Reactions: Effect of Nucleophile and Total Synthesis of (+)-(S,S)-(cis-6-methyltetrahydropyran-2-yl)acetic Acid and its trans-Diastereomer," Tetrahedron 2005, 61, 11679-11685
  9. Evans, P. A.; Cui, J.; Gharpure, S. J; Hinkle, R. J. “ Stereoselective Construction of Cyclic Ethers using a Tandem Two-Component Etherification: Elucidation of the Role of Bismuth Tribromide,” J. Am. Chem. Soc. 2003, 125,11456-11457.
  10. Hinkle, R. J. "Mikowski, A.M. "Kinetics of Stereoisomeric 2-Methyl-1-butenyl(aryl)iodonium triflates," Included in a special issue of ARKIVOC 2003, vi, 201-212, published 25 July 2003:
  11. Tykwinski, R. R. †; Kamada, K. ‡; Bykowski, D. †; Hegmann, F. A. †; Hinkle, R. J. "Nonlinear Optical Properties of Thienyl and Bithienyl Iodonium Salts as Measured by the Z-scan Technique," J. Opt. A: Pure Appl. Opt. 2002, 4, S202-206. .
  12. Bykowski, D. †; McDonald, R. †; Hinkle, R. J.; Tykwinski, R. R. † "Structural and Electronic Characteristics of Thienyl(aryl)iodonium Triflates," J. Org. Chem., 2002, 67, 2798-2804.
  13. Hinkle, R. J.; McDonald, R. †, "(Z)-2-Methyl-1-buten-1-yl(aryl)iodonium Triflates Containing Electron-Withdrawing Groups on the Aryl Moiety." Acta Cryst. C. 2002, C58, o117-o121.
  14. McNeil, A. J. ; Hinkle, R. J.; Rouse, E. A.; Thomas, Q. A.; Thomas, D. B. "Vinyl Carbocations: Solution Studies of Alkenyl(aryl)iodonium Triflate Fragmentations," J. Org. Chem. 2001 , 66, 5556-5565.
  15. Hinkle, R. J.; Leri, A. C.; David, G. A.; Erwin, W. M. "Addition of Benzylzinc Halides to Alkenyl(phenyl)iodonium Triflates: Stereoselective Synthesis of Trisubstituted Alkenes," Org. Lett. 2000, 2, 1521-1523.
  16. Hinkle, R. J.; McNeil, A. J.; Thomas, Q. A.; Andrews, M. N. “Vinyl Cations in Solution: Kinetics and Products of Alkenyl(aryl)iodonium Salt Fragmentations,” J. Am. Chem. Soc. 1999, 121, 7437-7438.
  17. Hinkle, R. J.; Thomas, D. B. “Facile Fragmentations of Alkenyl(aryl)iodonium Triflates,” J. Org. Chem. 1997, 62, 7534-7535.
  18. Hinkle, R. J.; Stang, P. J. "Stereospecific Synthesis of Trisubstituted Alkenyl-(phenyl)iodonium Salts from Vinylstannanes" Synthesis 1994, 313.
  19. Hinkle, R. J.; Poulter, G. T.; Stang, P. J. "Palladium(II) and Copper(I) Co-Catalyzed Coupling of Stereodefined Alkenyl(phenyl)iodonium Salts and Unsaturated Tri-n-butylstannanes" J. Am. Chem. Soc. 1993, 115, 11626.
  20. Hinkle, R. J.; Stang, P. J.; Arif, A. M. "Vinylplatinum Carbenes and Nitriles, Platinoxa-cyclic Complexes and Heck-Type Coupling Products Formed Via Reaction of ( sigma-2-propenyl)bis(triphenylphosphine)platinum(II) Triflate with Alkynols, Nitriles, and Acrylate Esters. Molecular Structure of [(PPh3)2PtCH2C(O)OCH3][OTf]" Organometallics 1993, 12, 3510.
  21. Zhong, Z.; Hinkle, R. J.; Arif, A. M.; Stang, P. J. "Novel Synthesis of eta-3-Allyl)platinum(II) Complexes from Enol Triflates and Simple Olefins and Their Regiospecific Deprotonation" J. Am. Chem. Soc. 1991, 113, 6196.
  22. 17) Hinkle, R. J.; Stang, P. J.; Kowalski, M. H. "Vinylphosphonium Salts: Stereoselective Palladium-Catalyzed Vinylation of Triphenylphosphine with Vinyl Triflates" J. Org. Chem. 1990, 55, 5033.
  23. Kowalski, M. H.; Hinkle, R. J.; Stang, P. J. "A Simple Highly Stereospecific Preparation of Vinylphosphonium Salts: Palladium-Catalyzed Vinylation of Triphenyphosphine via Vinyl Triflates" J. Org. Chem. 1989, 54, 2783.
  24. Pike, R. M.; Mayo, D. W.; Butcher, S. S.; Butcher, D. J.; Hinkle, R. J., "Microscale Organic Laboratory IV: A Simple and Rapid Procedure for Carrying Out Wittig Reactions " J. Chem. Ed. 1986, 63, 917.

† University of Alberta, Edmonton, Alberta, Canada